In recent years, probiotics have come into the limelight, which are active microorganisms that are beneficial to the body and can improve micro-ecological balance and maintain intestinal health.
Recently, probiotics have been found to have surprising effects in reducing acute kidney injury and delaying chronic complications in mice, so let's find out.
What is the role of probiotics in kidney damage?
A study was published in a subjournal of Cell in which the team demonstrated that supplementation with Lactobacillus casei was beneficial to the kidneys, reducing acute kidney injury and delaying the development of chronic kidney disease in mice. Targeting patients with stage 3-5 chronic kidney disease, Lactobacillus casei supplementation was found to be safe and beneficial in delaying the decline of kidney function.
To be able to verify the effect of Lactobacillus casei in vivo, the research team put 62 patients with chronic kidney disease stages 3 to 5 in a clinical trial and randomized them to receive placebo in group A and Lactobacillus casei in group B, each receiving treatment for 3 months.
The results showed that serum cystatin C was increased in group A and decreased in group B. The results showed that serum cystatin C was increased in group A and decreased in group B. The study suggests that Lactobacillus casei can improve intestinal flora and increase serum and renal levels of nicotinamide and short-chain fatty acids, thereby reducing kidney damage and delaying the development of chronic kidney disease.
What are the complications of acute kidney injury?
1、Nervous system diseases
As the kidney function is impaired, it is unable to remove metabolic wastes and toxins from the body, allowing these substances to accumulate in the body, thus poisoning the nervous system and inducing neurological complications, the main symptoms of which are memory and cognitive deficits, sleep disturbances and drowsiness.
Acute kidney injury will increase the content of metabolic waste in the intestinal tract, and the microorganisms parasitic in the intestinal tract will decompose urea into ammonia, which can directly stimulate the mucous membrane of the gastrointestinal tract, thus inducing inflammation and small superficial ulcers and predisposing to gastrointestinal diseases, whose main symptoms are loss of appetite, nausea and vomiting, anorexia and indigestion.
Because bacteria can break down the urea in saliva and produce too much ammonia, making the patient's mouth exhale a urine smell. In addition, acute kidney damage can also lead to respiratory complications such as pulmonary edema, pulmonary calcification and pleurisy, which are closely related to water and sodium retention and hypoproteinemia.
Most patients with acute kidney damage have varying degrees of renal hypertension, which, combined with the accumulation of large amounts of toxic substances, water and sodium retention, and hyperkalemia, as well as acidosis and anemia, predispose them to heart failure and arrhythmias; aseptic pericarditis can be induced because of stimulation by urea.
How to prevent acute kidney injury?
1、Do not abuse drugs
Most of the drugs are excreted by the kidneys, and some of them can produce nephrotoxicity, so you should not use them arbitrarily, and you should follow the doctor's advice if necessary and do kidney-related examination regularly during the medication.
2、Actively prevent infection
Infections are a major contributor to acute kidney damage, including urinary tract infections, respiratory tract infections, gastrointestinal tract, and oral infections. Therefore, it is important to pay attention to personal hygiene, change clothes close to the body regularly, and increase clothes according to weather changes. After inadvertent infection, antibiotics should be used in full amount and in full course to remove the foci of infection in a timely manner.
Patients with acute kidney injury should rest more in bed and provide a quiet sleeping environment, which can reduce metabolism and the burden on the kidneys. Provide a diet with less salt, less fat, less sugar and high calcium and high quality low protein, and control water, potassium and sodium intake appropriately. Insist on daily weight measurement to facilitate the understanding of water retention.
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