According to the editor of "TOP University is here", on Nov. 18, Science published online the research paper of Prof. Wang Lei's team from the Pediatric Hospital of Fudan University. This is the second time that Fudan University has been published in the international top journal within two days after the publication of the research results of Prof. Guihua Wang's team in the Department of Atmospheric and Oceanic Sciences/Institute of Atmospheric Sciences of Fudan University in Nature on Nov. 17.
Turning perceptions upside down! Fudan University team unravels the unique mechanism of spindle assembly in human oocytes
According to the editor of TOP University, on November 18, Wang Lei and Sang Qing's team from the Pediatric Hospital of Fudan University and the Institute of Biomedical Research of Fudan University published a research paper entitled "The mechanism of acentrosomal spindle assembly in human oocytes" in the global top scientific journal "Science" in collaboration with Sun Xiaoxi from Ji'ai Genetic and Infertility Clinic of the Obstetrics and Gynecology Hospital of Fudan University.
Affiliated Pediatric Hospital of Fudan University, Tanyu Wu, Institute of Biomedical Research of Fudan University, Jie Dong, PhD student (graduated), Jing Fu, Shanghai Ji'ai Genetic and Infertility Clinic, and Yanping Kuang, Reproduction Center, Ninth People's Hospital of Shanghai Jiaotong University are co-first authors of this article.
A research team from Fudan University has identified a previously unknown and distinctive microtubule organizing center in human oocytes, named it hooMTOC (Human Oocyte Microtubule Organizing Center), clarified the related molecular composition, elucidated the physiological mechanism of spindle assembly initiation in human oocytes, and finally identified mutations in hooMTOC components in patients with abnormal oocyte spindle assembly, revealing a new mechanism of human oocyte spindle assembly from a physiopathological perspective.
In summary, the researchers identified for the first time a novel submicroscopic structure called hooMTOC that assembles spindle microtubules in human oocytes, and elucidated the unique physiological mechanism by which hooMTOC regulates spindle assembly in human oocytes, while revealing that abnormal hooMTOC leads to impaired oocyte maturation in patients, contributing to a new understanding of the pathological mechanism of this disease.
Fudan University team found a significant increase in global typhoons in the last 30 years
According to the editor of TOP University, on November 17, Wang Guihua, the corresponding author and first author of a paper by the Department of Atmospheric and Oceanic Sciences/Institute of Atmospheric Sciences of Fudan University, published a research paper entitled "Ocean currents show global intensification of weak tropical cyclones" in the global top scientific journal "Nature".
The joint research team proposes to estimate typhoon intensity using high precision ocean mixed layer current velocities observed by drifting buoys (drifter) on the sea surface. The analysis of global mixed layer current velocity data from a large number of drifter observations for the period 1991-2020 reveals that the weak typhoons, which account for 70% of the world's typhoons in the last 30 years, have a significant strengthening trend at both the global and basin scales.
Professor Guihua Wang's group calculated the mixed layer flow velocity trends under weak typhoon conditions for the period 1991-2020 (Figure 2 in the original text). The results show that the mixed layer velocities in all ocean basins under weak typhoon conditions show an obvious increasing trend, and the increasing trend of mixed layer velocities under weak typhoon conditions in the North Atlantic, Northeast Pacific, Northwest Pacific, South Indian Ocean and South Pacific are about 0.35, 0.29, 0.36, 0.39 and 0.54 cm s-1 a-1, respectively. This indicates that there is an increasing trend of 0.18 m s-1 a-1 in the global weak typhoon in the last 30 years.
The finding that global weak typhoons have increased significantly in the last 30 years confirms to a certain extent the theory that global warming causes typhoons to increase, and will help to improve the prediction of future typhoon intensity changes. Due to the limitation of drifter data volume, this work mainly focuses on weak typhoons, but in the northwest Pacific Ocean, where drifting buoy observations are relatively abundant, the authors found that strong typhoons have also strengthened in the last 30 years. With the accumulation of observational data, the new method proposed in this study for inferring typhoon intensity from ocean mixed layer current velocities can be used for the analysis of intensity changes of all typhoons globally, providing an important basis for further improving typhoon simulation and prediction accuracy.
Reviewed and edited by Daco
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