Per Einstein's theory of relativity, interstellar travel is possible—or at least possible within human lifetimes.
The reason is acceleration. Humans are fairly puny creatures, and we can’t stand much acceleration. Impose much more than 1 g of acceleration onto a human for an extended period of time, and we will experience all kinds of health problems. (Impose much more than 10 g and these health problems will include immediate unconsciousness and a rapid death.)
To travel anywhere significant, we need to accelerate up to your travel speed, and then decelerate again at the other end. If we’re limited to, say, 1.5 g for extended periods, then in a non-relativistic, Newtonian world, this gives us a major problem: Everyone’s going to die before we get there. The only way of getting the time down is to apply stronger accelerations, so we need to send robots, or at least something much tougher than we delicate bags of mostly water.
But relativity helps a lot. As soon as we get anywhere near the speed of light, then the local time on the spaceship dilates, and we can get to places in much less (spaceship) time than it would take in a Newtonian universe. (Or, looking at it from the point of view of someone on the spaceship: they will see the distances contract as they accelerate up to near light-speed—the effect is the same, they will get there quicker.)
Here’s a quick table I knocked together on the assumption that we can’t accelerate any faster than 1.5 g. We accelerate up at that rate for half the journey, and then decelerate at the same rate in the second half to stop just beside wherever we are visiting.
You can see that to get to destinations much beyond 50 light years away, we are receiving massive advantages from relativity. And beyond 1000 light years, it’s only thanks to relativistic effects that we’re getting there within a human lifetime.
Indeed, if we continue the table, we’ll find that we can get across the entire visible universe (47 billion light-years or so) within a human lifetime (28 years or so) by exploiting relativistic effects.
So, by using relativity, it seems we can get anywhere we like! Well ... not quite. Two problems.
First, the effect is only available to the travelers. The Earth times will be much much longer. (Rough rule to obtain the Earth-time for a return journey [is to] double the number of light years in the table and add 0.25 to get the time in years). So if they return, they will find many thousand years have elapsed on earth: their families will live and die without them. So, even we did send explorers, we on Earth would never find out what they had discovered. Though perhaps for some explorers, even this would be a positive: “Take a trip to Betelgeuse! For only an 18 year round-trip, you get an interstellar adventure and a bonus: time-travel to 1300 years in the Earth’s future!”
Second, a more immediate and practical problem: The amount of energy it takes to accelerate something up to the relativistic speeds we are using here is—quite literally—astronomical. Taking the journey to the Crab Nebula as an example, we’d need to provide about 7×1020 J of kinetic energy per kilogram of spaceship to get up to the top speed we’re using.
That is a lot. But it’s available: the Sun puts out 3X1026 W, so in theory, you’d only need a few seconds of Solar output (plus a Dyson Sphere) to collect enough energy to get a reasonably sized ship up to that speed. This also assumes you can transfer this energy to the ship without increasing its mass: e.g., via a laser anchored to a large planet or star; if our ship needs to carry its chemical or matter/anti-matter fuel and accelerate that too, then you run into the “tyranny of the rocket equation” and we’re lost. Many orders of magnitude more fuel will be needed.
But I’m just going to airily treat all that as an engineering issue (albeit one far beyond anything we can attack with currently imaginable technology). Assuming we can get our spaceships up to those speeds, we can see how relativity helps interstellar travel. Counter-intuitive, but true.