Core summary.
1. Recurrence of positive test results refers to the re-emergence of positive test results in newly coronavirus-infected patients who have met the discharge criteria after their nucleic acid test results have turned negative. Academician Zhong Nanshan led a study of 158 locally infected patients with Delta strain admitted to Guangzhou Medical University in 2021, and 679 infected patients imported from abroad: 77 of the local cases showed a re-positive test, with a rate of 48.73%; 437 of the imported cases from abroad showed a re-positive test, with a rate of 64.36%.
2. A team led by Academician Zhong Nanshan published a collaborative study in the National Science Review, which showed that no new coronary infected patients who regained their positive status were found to be at risk of transmission, and that patients who regained their positive status did not show increased clinical symptoms and did not need to be hospitalized.
3. The results of the study show that although the viral load of those infected with the Delta strain who regained positivity had a low viral load, the time to regain positivity was longer, with about a quarter or more of those infected showing positive results on nucleic acid tests for a long time. Some data suggest that the viral load of Omicron-infected patients is not lower than that of Delta, and that the percentage of re-positives is not lower.
4. Newly crowned infected people eventually beat the virus but face much discrimination in their life and work. In fact, based on the understanding of the virus, the health committee is also updating the anti-epidemic policy, such as lowering the Ct threshold of nucleic acid test for re-positive. Therefore, since re-positives are not at risk of transmission, we should take more measures based on scientific data to mitigate the cost of anti-epidemic. At the same time, let them stop living in a highly discriminatory environment.
Author｜Zhang Hongtao
Ph.D. in Pharmacology, Phoenix Oncology Intelligence Specialists
Delta variant has a 60% re-positive rate in those infected
However, the re-positive person is not found to be infectious and does not need to be hospitalized
Is it possible to retransmit after being infected with Neoconvoyant?
Can a rejuvenated patient re-enter the workforce, get married or return to society?
There is now a standard scientific answer to the problem of discrimination against the 230,000 diagnosed and 500,000 asymptomatic infected people in China.
The results of the study, led by Academician Zhong Nanshan and published recently in the National Science Review, show that there is no risk of transmission for newly crowned infected people who are re-positive!
In addition, patients with re-surgery did not show an increase in clinical symptoms and did not need to be hospitalized.
This is a collaborative study, and the research team includes the team of academician Zhong Nanshan from Guangzhou National Laboratory, the team of Tang Xiaoping/Li Feng from City Eight Hospital of Guangzhou Medical University, the team of Li Yan/Ke Changwen from Guangdong CDC and the team of Lu Hongzhou from Shenzhen Third People's Hospital.
The patients examined in this study, who were infected with the Delta variant, were 837 in total, including indigenous infections found in Guangzhou city (158 cases) and imported infections from abroad (679 cases), and were all cases admitted to Guangzhou Medical University in 2021.
A re-positive, which refers to a person infected with the virus meeting the discharge criteria associated with nucleic acid treatment after a negative nucleic acid test result, but reappears with a positive test result. Among the 158 indigenous infections mentioned above, 77 cases showed a re-positive test, or 48.73%, and among the 679 imported infections from abroad, 437 cases showed a re-positive test, or 64.36%.
Overall, the rate of reversion in those infected with the Delta variant was much higher than the 7.2% reversion rate following infection with the earlier wild-type strain of the virus.
The emergence of compound yang places a huge burden on patients, communities and society.
However, this latest study found that none of the 25 upper-breath samples available from the repositives were cultured with a virus that could infect the cells. In some samples, the viral load was not low, with Ct values ranging from 25 to 29 for nucleic acid testing, and even so, no live virus was detected.
Of these total repositives, 23 were found in the community, and the associated flow survey traced 259 close contacts, but none were infected by the repositives!
Those who have regained their positivity are not worse and do not require hospitalization
Recurrence of the disease in an infected person does not mean that the disease has become malignant
In addition, the study also found that patients with re-surgery did not show an increase in clinical symptoms and did not require hospitalization.
Only 6.57% of those with a complete record of recurrent positives had clinical symptoms, including cough, sputum, throat discomfort, and fatigue.
During the period of admission for observation, the immune cell ratio of the repositive patients returned to the normal range. Even though the amount of virus in the patient's body increased after reassociation, the lung damage did not become more severe as a result. With the exception of a small number of severe patients, the inflammation in the lungs of most of the re-positives was also further absorbed during the isolation and observation period.
Since the health condition of the rebounded person is still gradually improving, the rebound is also a process of recovery and does not mean that the condition has become malignant.
Research by Academician Zhong Nanshan and other teams has shown that there is no risk of infection and no need for treatment, and if these people have to be isolated again, the result will only be a drain on social resources, depletion of national financial resources, and an unwarranted increase in the risk of medical resources being squeezed.
The percentage of rejuvenation lasting more than 42 days is 45%
Vaccination does not prevent recurrence, study finds
Compared to those infected with the previous strain of the virus, the amount of virus in those infected with the Delta variant has soared by a factor of 1,000! It is probably because the viral load of Delta is so high that the use of very sensitive nucleic acid tests naturally leads to an increased percentage of repeat positives.
At the time of the Delta outbreak in Guangzhou, there were already many people who had received the New Crown vaccine. Analysis found that vaccination did not prevent the occurrence of recurrent positives. This result was disappointing, but examination of those who had regained their positives found that a smaller percentage of those who had been vaccinated developed pneumonia. This is still at least good news.
The Ct value of the nucleic acid test corresponds inversely to the amount of virus; the higher the Ct value, the lower the amount of virus. The results of the analysis showed that the amount of virus was lower in the re-positives, with 93.6% of the re-positives having Ct values above 30. Overall, the re-positives had a 100,000-1 million times lower viral load than at the time of initial infection.
Although the viral load was relatively low, 45% of the indigenous infections, however, lasted for more than 42 days of reassurance!
This data is also amazing! As mentioned earlier, 60% of those infected with Delta will come back positive, so that means that more than a quarter of those infected will test positive for nucleic acid for a very long time.
A very small number of re-positives lasted even 120 days because of a high viral load!
A bizarre case of out-of-country imported cases.
Negative initial nucleic acid test, but positive nucleic acid on re-positive
In this study, there is another phenomenon worth mentioning.
There were 162 imported infected persons from outside the country who were initially admitted to the hospital with negative nucleic acid test results. However, after the re-positive, the nucleic acid test results were positive, while some of the re-positives lasted for a long time.
These 162 foreign-imported infected patients were already at the end stage of infection when they were first admitted to the hospital, which is why the nucleic acid test results were negative. The highest Ct value of the nucleic acid test was also higher than 30 after the re-positive, indicating a very low viral load.
The current global outbreak is ongoing and the large number of imported cases from abroad has led to a meltdown of international flights. Some say this is because someone used a forged negative nucleic acid certificate before boarding, but could there be a more general possibility: due to the widespread epidemic and the large percentage of infected people, many people have turned negative for nucleic acid after infection, but due to the high percentage of re-positives, even if they were negative before boarding, they are likely to turn positive after entry.
These also need further and greater research.
Is it possible that the proportion of Omicron compound positives exceeds that of the Delta variant?
How long does it take to regain sunlight? There is no exact data
The conclusion that "re-positives are not infectious" was actually known in 2020. in May 2020, the CDC conducted an epidemiological survey of 285 re-positives, who had been outside freely for an average of two weeks from the time of release to re-positive, but did not infect any close persons as a result .
The outbreak has been raging for almost three years. According to data released by the Health Commission, as of Aug. 12, a total of 234,217 confirmed cases had been reported, a number that does not include the hundreds of thousands of asymptomatic positive infections.
Most of the infections in China arose during this year's Omicron outbreak. The above study is based on data from the Delta mutant strain. What exactly is the percentage of Omicron-infected patients who regained their positivity? How long does it take to regain positivity? There is no exact data available.
However, the viral load of Omicron infection is not lower than that of Delta, and the percentage of repositives is not lower. In the United States, Dr. Fauci and President Biden are all repositives and have also taken the antiviral oral drug paxlovid. clinical trials were conducted when the haunting was still the previous mutant strain. There are now data showing that after taking paxlovid, a higher percentage of Omicron-infected people are re-positive than in previous clinical trials.
So, the Omicron rejuvenator, there may be more.
Why is it a group that is discriminated against?
Can the Ct value be modified to 30 to allow home isolation for repeat positives?
While it is unfortunate that the phenomenon of recurrence after a new coronary infection is an unfortunate one, it is even more unfortunate that not only do a large number of people who have recurred live in the shadow of the infection, but those who have fully recovered also face possible discrimination. Those who have regained their positive status have defeated the virus, but have been ostracized and isolated just like the virus. In the aftermath of the Shanghai epidemic, some companies recruited "those who have been in the square cabin, and those who have been positive, don't".
The social problems of "not being able to find a job" and "not being able to afford to stay in a hotel" have attracted the attention of the media.
Although many experts have pointed out in the media that those who have regained their positive status "have not caused any further spread of the epidemic or infection," discrimination against those infected will not be eliminated overnight because of the group fear of the virus.
When the outbreak occurred in 2020, we knew nothing about the new coronavirus. More than two years later, there are already 600 million confirmed infections worldwide, with many more undiagnosed. We should know more about the new coronavirus than any other virus.
However, we seem to be living in the same fear as before.
In fact, based on the understanding of the virus, the health committee is updating its vaccination policy. For example, after Delta, the Ct threshold for nucleic acid testing for repositives has been changed from 40 to 35, which means that people who would have been labeled as "repositives" under the previous criteria can now not be treated as repositives. This is a huge improvement that should benefit hundreds of thousands of people.
However, in the above-mentioned study, there were some repositives with Ct values less than 35, which would still wear the "repositive" label today.
Perhaps we should take a bigger step forward and change the Ct value to 30. since the repeat positives are not at risk of transmission, we should allow them to be isolated at home.
These measures, grounded in scientific data, should greatly reduce the cost of our fight against the epidemic.
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